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Overcoming Phase‐Transfer Limitations in the Conversion of Lipophilic Oleo Compounds in Aqueous Media—A Thermomorphic Approach
Author(s) -
Gaide Tom,
Dreimann Jens M.,
Behr Arno,
Vorholt Andreas J.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201510738
Subject(s) - hydroformylation , catalysis , aqueous two phase system , aqueous solution , aqueous medium , solvent , butanol , robustness (evolution) , chemistry , chemical engineering , organic chemistry , materials science , ethanol , engineering , biochemistry , rhodium , gene
A new process concept has been developed for recycling transition‐metal catalysts in the synthesis of moderately polar products via aqueous thermomorphic multicomponent solvent systems. This work focuses on the use of “green” solvents (1‐butanol and water) in the hydroformylation of the bio‐based substrate methyl 10‐undecenoate. Following the successful development of a biphasic reaction system on the laboratory scale, the reaction was transferred to a continuously operated miniplant to demonstrate the robustness of this innovative recycling concept for homogenous catalysts.