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Silver‐Catalyzed 7 ‐exo‐ dig Cyclization of Silylenolether‐ynesulfonamides
Author(s) -
Heinrich Clément F.,
Fabre Indira,
Miesch Laurence
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201510708
Subject(s) - dig , catalysis , chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , computer science , world wide web
Cyclization of silylenolether‐ynesulfonamides proceeds at ambient temperature under mild reaction conditions under silver catalysis. Bridged compounds were obtained exclusively through 7 ‐exo‐ dig reactions. The protocol is applicable to a wide range of substrates, thus leading to azabicyclic frameworks.