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Mild Cobalt‐Catalyzed Negishi Cross‐Couplings of (Hetero)arylzinc Reagents with (Hetero)aryl Halides
Author(s) -
Haas Diana,
Hammann Jeffrey M.,
Lutter Ferdinand H.,
Knochel Paul
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201510665
Subject(s) - reagent , negishi coupling , aryl , halide , catalysis , chemistry , cobalt , combinatorial chemistry , organic chemistry , alkyl
A catalytic system consisting of CoCl 2 ⋅ 2 LiCl (5 mol %) and HCO 2 Na (50 mol %) enables the cross‐coupling of various N‐heterocyclic chlorides and bromides as well as aromatic halogenated ketones with various electron‐rich and ‐poor arylzinc reagents. The reactions reached full conversion within a few hours at 25 °C.
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