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Degradable Molybdenum Oxide Nanosheets with Rapid Clearance and Efficient Tumor Homing Capabilities as a Therapeutic Nanoplatform
Author(s) -
Song Guosheng,
Hao Jiali,
Liang Chao,
Liu Teng,
Gao Min,
Cheng Liang,
Hu Junqing,
Liu Zhuang
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201510597
Subject(s) - polyethylene glycol , peg ratio , photothermal therapy , chemistry , molybdenum , absorbance , materials science , nanotechnology , inorganic chemistry , organic chemistry , chromatography , finance , economics
Molybdenum oxide (MoOx) nanosheets with high near‐infrared (NIR) absorbance and pH‐dependent oxidative degradation properties were synthesized, functionalized with polyethylene glycol (PEG), and then used as a degradable photothermal agent and drug carrier. The nanosheets, which are relatively stable under acidic pH, could be degraded at physiological pH. Therefore, MoOx‐PEG distributed in organs upon intravenous injection would be rapidly degraded and excreted without apparent in vivo toxicity. MoOx‐PEG shows efficient accumulation in tumors, the acidic pH of which then leads to longer tumor retention of those nanosheets. Along with the capability of acting as a photothermal agent for effective tumor ablation, MoOx‐PEG can load therapeutic molecules with high efficiencies. This concept of inorganic theranostic nanoagent should be relatively stable in tumors to allow imaging and treatment, while being readily degradable in normal organs to enable rapid excretion and avoid long‐term retention/toxicity.