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Size‐Controlled Formation of Noble‐Metal Nanoparticles in Aqueous Solution with a Thiol‐Free Tripeptide
Author(s) -
Corra Stefano,
Lewandowska Urszula,
Benetti Edmondo M.,
Wennemers Helma
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201510337
Subject(s) - tripeptide , dispersity , noble metal , nanoparticle , aqueous solution , peptide , metal , monolayer , chemistry , palladium , nanotechnology , materials science , combinatorial chemistry , polymer chemistry , organic chemistry , catalysis , biochemistry
A combinatorial screening revealed the peptide H‐His‐ d ‐Leu‐ d ‐Asp‐NH 2 ( 1 ) as an additive for the generation of monodisperse, water‐soluble palladium nanoparticles with average diameters of 3 nm and stabilities of over 9 months. The tripeptide proved to be also applicable for the size‐controlled formation of other noble‐metal nanoparticles (Pt and Au). Studies with close analogues of peptide 1 revealed a specific role of each of the three amino acids for the formation and stabilization of the nanoparticles. These data combined with microscopic and spectroscopic analyses provided insight into the structure of the self‐assembled peptidic monolayer around the metal core. The results open interesting prospects for the development of functionalized metal nanoparticles.