Photoresponsive Formation of an Intermolecular Minimal G‐Quadruplex Motif | Zendy

Thevarpadam Julie | Zendy; Bessi Irene | Zendy; Binas Oliver | Zendy; Gonçalves Diana P. N. | Zendy; Slavov Chavdar | Zendy; Jonker Hendrik R. A. | Zendy; Richter Christian | Zendy; Wachtveitl Josef | Zendy; Schwalbe Harald | Zendy; Heckel Alexander | Zendy

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Photoresponsive Formation of an Intermolecular Minimal G‐Quadruplex Motif

Author(s) -

Thevarpadam Julie,

Bessi Irene,

Binas Oliver,

Gonçalves Diana P. N.,

Slavov Chavdar,

Jonker Hendrik R. A.,

Richter Christian,

Wachtveitl Josef,

Schwalbe Harald,

Heckel Alexander

Publication year - 2016

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201510269

Subject(s) - azobenzene , intermolecular force , chemistry , isomerization , circular dichroism , photoisomerization , tetrad , intramolecular force , g quadruplex , linker , bifunctional , crystallography , structural motif , photochemistry , stereochemistry , molecule , dna , organic chemistry , biochemistry , botany , operating system , computer science , biology , catalysis

The ability of three different bifunctional azobenzene linkers to enable the photoreversible formation of a defined intermolecular two‐tetrad G‐quadruplex upon UV/Vis irradiation was investigated. Circular dichroism and NMR spectroscopic data showed the formation of G‐quadruplexes with K + ions at room temperature in all three cases with the corresponding azobenzene linker in an E conformation. However, only the para – para ‐substituted azobenzene derivative enables photoswitching between a nonpolymorphic, stacked, tetramolecular G‐quadruplex and an unstructured state after E – Z isomerization.

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