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Photoresponsive Formation of an Intermolecular Minimal G‐Quadruplex Motif
Author(s) -
Thevarpadam Julie,
Bessi Irene,
Binas Oliver,
Gonçalves Diana P. N.,
Slavov Chavdar,
Jonker Hendrik R. A.,
Richter Christian,
Wachtveitl Josef,
Schwalbe Harald,
Heckel Alexander
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201510269
Subject(s) - azobenzene , intermolecular force , chemistry , isomerization , circular dichroism , photoisomerization , tetrad , intramolecular force , g quadruplex , linker , bifunctional , crystallography , structural motif , photochemistry , stereochemistry , molecule , dna , organic chemistry , biochemistry , botany , operating system , computer science , biology , catalysis
The ability of three different bifunctional azobenzene linkers to enable the photoreversible formation of a defined intermolecular two‐tetrad G‐quadruplex upon UV/Vis irradiation was investigated. Circular dichroism and NMR spectroscopic data showed the formation of G‐quadruplexes with K + ions at room temperature in all three cases with the corresponding azobenzene linker in an E conformation. However, only the para – para ‐substituted azobenzene derivative enables photoswitching between a nonpolymorphic, stacked, tetramolecular G‐quadruplex and an unstructured state after E – Z isomerization.