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Recognition and Sensing of Creatinine
Author(s) -
Guinovart Tomàs,
HernándezAlonso Daniel,
Adriaenssens Louis,
Blondeau Pascal,
MartínezBelmonte Marta,
Rius F. Xavier,
Andrade Francisco J.,
Ballester Pablo
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201510136
Subject(s) - creatinine , potentiometric titration , chemistry , membrane , simplicity , combinatorial chemistry , computer science , ion , organic chemistry , biochemistry , philosophy , epistemology
Current methods for creatinine quantification suffer from significant drawbacks when aiming to combine accuracy, simplicity, and affordability. Here, an unprecedented synthetic receptor, an aryl‐substituted calix[4]pyrrole with a monophosphonate bridge, is reported that displays remarkable affinity for creatinine and the creatininium cation. The receptor works by including the guest in its deep and polar aromatic cavity and establishing directional interactions in three dimensions. When incorporated into a suitable polymeric membrane, this molecule acts as an ionophore. A highly sensitive and selective potentiometric sensor suitable for the determination of creatinine levels in biological fluids, such as urine or plasma, in an accurate, fast, simple, and cost‐effective way has thus been developed.