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Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction
Author(s) -
Zhang Chen,
Bu Wenbo,
Ni Dalong,
Zhang Shenjian,
Li Qing,
Yao Zhenwei,
Zhang Jiawen,
Yao Heliang,
Wang Zheng,
Shi Jianlin
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201510031
Subject(s) - disproportionation , materials science , ferrous , cancer therapy , nanocrystal , fenton reaction , amorphous solid , nanoparticle , cancer , nanotechnology , chemical engineering , chemistry , catalysis , metallurgy , biochemistry , organic chemistry , medicine , engineering
Metallic glasses and cancer theranostics are emerging fields that do not seem to be related to each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) and their superior physicochemical properties compared to their crystalline counterpart, iron nanocrystals (FeNCs). The AFeNPs can be used for cancer theranostics by inducing a Fenton reaction in the tumor by taking advantage of the mild acidity and the overproduced H 2 O 2 in a tumor microenvironment: Ionization of the AFeNPs enables on‐demand ferrous ion release in the tumor, and subsequent H 2 O 2 disproportionation leads to efficient . OH generation. The endogenous stimuli‐responsive . OH generation in the presence AFeNPs enables a highly specific cancer therapy without the need for external energy input.