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Simultaneous Dual Encoding of Three‐Dimensional Structures by Light‐Induced Modular Ligation
Author(s) -
Claus Tanja K.,
Richter Benjamin,
Hahn Vincent,
Welle Alexander,
Kayser Sven,
Wegener Martin,
Bastmeyer Martin,
Delaittre Guillaume,
BarnerKowollik Christopher
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201509937
Subject(s) - surface modification , materials science , polymerization , monomer , ethylene glycol , fabrication , modular design , dual (grammatical number) , combinatorial chemistry , nanotechnology , chemistry , polymer , computer science , organic chemistry , composite material , medicine , alternative medicine , pathology , operating system , art , literature
A highly efficient strategy for the simultaneous dual surface encoding of 2D and 3D microscaffolds is reported. The combination of an oligo(ethylene glycol)‐based network with two novel and readily synthesized monomers with photoreactive side chains yields two new photoresists, which can be used for the fabrication of microstructures (by two‐photon polymerization) that exhibit a dual‐photoreactive surface. By combining both functional photoresists into one scaffold, a dual functionalization pattern can be obtained by a single irradiation step in the presence of adequate reaction partners based on a self‐sorting mechanism. The versatility of the approach is shown by the dual patterning of halogenated and fluorescent markers as well as proteins. Furthermore, we introduce a new ToF–SIMS mode (“delayed extraction”) for the characterization of the obtained microstructures that combines high mass resolution with improved lateral resolution.