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Organocatalytic Enantioselective Synthesis of 1,4‐Dioxanes and Other Oxa‐Heterocycles by Oxetane Desymmetrization
Author(s) -
Yang Wen,
Sun Jianwei
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201509888
Subject(s) - desymmetrization , enantioselective synthesis , oxetane , organocatalysis , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis
A new asymmetric synthesis of chiral 1,4‐dioxanes and other oxa‐heterocycles has been developed by means of organocatalytic enantioselective desymmetrization of oxetanes. This mild process proceeds with exceedingly high efficiency and enantioselectivity to establish the quaternary stereocenters. This method complements the existing, yet limited, strategies for the synthesis of these oxa‐heterocycles.