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Simple Peptide‐Tuned Self‐Assembly of Photosensitizers towards Anticancer Photodynamic Therapy
Author(s) -
Liu Kai,
Xing Ruirui,
Zou Qianli,
Ma Guanghui,
Möhwald Helmuth,
Yan Xuehai
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201509810
Subject(s) - photodynamic therapy , biodistribution , peptide , in vivo , dipeptide , amphiphile , drug , photosensitizer , drug delivery , nanotechnology , phototoxicity , biophysics , in vitro , materials science , chemistry , pharmacology , medicine , biochemistry , biology , photochemistry , organic chemistry , microbiology and biotechnology , copolymer , polymer
Abstract Peptide‐tuned self‐assembly of functional components offers a strategy towards improved properties and unique functions of materials, but the requirement of many different functions and a lack of understanding of complex structures present a high barrier for applications. Herein, we report a photosensitive drug delivery system for photodynamic therapy (PDT) by a simple dipeptide‐ or amphiphilic amino‐acid‐tuned self‐assembly of photosensitizers (PSs). The assembled nanodrugs exhibit multiple favorable therapeutic features, including tunable size, high loading efficiency, and on‐demand drug release responding to pH, surfactant, and enzyme stimuli, as well as preferable cellular uptake and biodistribution. These features result in greatly enhanced PDT efficacy in vitro and in vivo, leading to almost complete tumor eradication in mice receiving a single drug dose and a single exposure to light.