Premium
αvβ3‐ or α5β1‐Integrin‐Selective Peptidomimetics for Surface Coating
Author(s) -
MasMoruno Carlos,
Fraioli Roberta,
Rechenmacher Florian,
Neubauer Stefanie,
Kapp Tobias G.,
Kessler Horst
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201509782
Subject(s) - peptidomimetic , integrin , cell adhesion , chemistry , surface modification , adhesion , nanotechnology , cell , microbiology and biotechnology , biophysics , materials science , biochemistry , biology , peptide , organic chemistry
Engineering biomaterials with integrin‐binding activity is a very powerful approach to promote cell adhesion, modulate cell behavior, and induce specific biological responses at the surface level. The aim of this Review is to illustrate the evolution of surface‐coating molecules in this field: from peptides and proteins with relatively low integrin‐binding activity and receptor selectivity to highly active and selective peptidomimetic ligands. In particular, we will bring into focus the difficult challenge of achieving selectivity between the two closely related integrin subtypes αvβ3 and α5β1. The functionalization of surfaces with such peptidomimetics opens the way for a new generation of highly specific cell‐instructive surfaces to dissect the biological role of integrin subtypes and for application in tissue engineering and regenerative medicine.