Premium
Tailor‐Made Ruthenium‐Triphos Catalysts for the Selective Homogeneous Hydrogenation of Lactams
Author(s) -
Meuresch Markus,
Westhues Stefan,
Leitner Walter,
Klankermayer Jürgen
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201509650
Subject(s) - triphos , ruthenium , catalysis , homogeneous , selectivity , combinatorial chemistry , ligand (biochemistry) , chemistry , homogeneous catalysis , lactam , stereochemistry , organic chemistry , receptor , biochemistry , physics , thermodynamics
The development of a tailored tridentate ligand enabled the synthesis of a molecular ruthenium‐triphos catalyst, eliminating dimerization as the major deactivation pathway. The novel catalyst design showed strongly increased performance and facilitated the hydrogenation of highly challenging lactam substrates with unprecedented activity and selectivity.