Expedient Iron‐Catalyzed C−H Allylation/Alkylation by Triazole Assistance with Ample Scope | Zendy

Cera Gianpiero | Zendy; Haven Tobias | Zendy; Ackermann Lutz | Zendy

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Expedient Iron‐Catalyzed C−H Allylation/Alkylation by Triazole Assistance with Ample Scope

Author(s) -

Cera Gianpiero,

Haven Tobias,

Ackermann Lutz

Publication year - 2016

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201509603

Subject(s) - alkylation , scope (computer science) , catalysis , chemistry , triazole , combinatorial chemistry , organic chemistry , computer science , programming language

Triazole assistance set the stage for a unified strategy for the iron‐catalyzed C−H allylation of arenes, heteroarenes, and alkenes with ample scope. The versatile catalyst also proved competent for site‐selective methylation, benzylation, and alkylation with challenging primary and secondary halides. Triazole‐assisted C−H activation proceeded chemo‐, site‐, and diastereo‐selectively, and the modular TAM directing group was readily removed in a traceless fashion under exceedingly mild reaction conditions.

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