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Enantioselective Synthesis of Atropisomeric Vinyl Arene Compounds by Palladium Catalysis: A Carbene Strategy
Author(s) -
Feng Jia,
Li Bin,
He Yun,
Gu Zhenhua
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201509571
Subject(s) - palladium , phosphine , enantioselective synthesis , carbene , chemistry , catalysis , aryl , combinatorial chemistry , organic chemistry , alkyl
An efficient palladium‐catalyzed asymmetric synthesis of axially chiral vinyl arenes from aryl bromides and hydrazones is reported. The products were easily oxidized to axially chiral biaryl compounds, and the phosphine oxides were readily reduced to phosphine ligands.