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Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins
Author(s) -
Zhu Xi,
Wu Jun,
Shan Wei,
Tao Wei,
Zhao Lili,
Lim JongMin,
D'Ortenzio Mathew,
Karnik Rohit,
Huang Yuan,
Shi Jinjun,
Farokhzad Omid C.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201509183
Subject(s) - transferrin , chemistry , in vivo , nanoparticle , biophysics , surface modification , nanotechnology , materials science , biochemistry , biology , microbiology and biotechnology
Effective delivery of therapeutic proteins is a formidable challenge. Herein, using a unique polymer family with a wide‐ranging set of cationic and hydrophobic features, we developed a novel nanoparticle (NP) platform capable of installing protein ligands on the particle surface and simultaneously carrying therapeutic proteins inside by a self‐assembly procedure. The loaded therapeutic proteins (e.g., insulin) within the NPs exhibited sustained and tunable release, while the surface‐coated protein ligands (e.g., transferrin) were demonstrated to alter the NP cellular behaviors. In vivo results revealed that the transferrin‐coated NPs can effectively be transported across the intestinal epithelium for oral insulin delivery, leading to a notable hypoglycemic response.