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Engineering Polymer Hydrogel Nanoparticles for Lymph Node‐Targeted Delivery
Author(s) -
De Koker Stefaan,
Cui Jiwei,
Vanparijs Nane,
Albertazzi Lorenzo,
Grooten Johan,
Caruso Frank,
De Geest Bruno G.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201508626
Subject(s) - immune system , pegylation , lymphatic system , priming (agriculture) , lymph node , antigen , in vivo , lymph , nanoparticle , materials science , chemistry , self healing hydrogels , acquired immune system , nanotechnology , immunology , medicine , biology , polyethylene glycol , biochemistry , pathology , polymer chemistry , botany , germination , microbiology and biotechnology
The induction of antigen‐specific adaptive immunity exclusively occurs in lymphoid organs. As a consequence, the efficacy by which vaccines reach these tissues strongly affects the efficacy of the vaccine. Here, we report the design of polymer hydrogel nanoparticles that efficiently target multiple immune cell subsets in the draining lymph nodes. Nanoparticles are fabricated by infiltrating mesoporous silica particles (ca. 200 nm) with poly(methacrylic acid) followed by disulfide‐based crosslinking and template removal. PEGylation of these nanoparticles does not affect their cellular association in vitro, but dramatically improves their lymphatic drainage in vivo. The functional relevance of these observations is further illustrated by the increased priming of antigen‐specific T cells. Our findings highlight the potential of engineered hydrogel nanoparticles for the lymphatic delivery of antigens and immune‐modulating compounds.