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Strong Bonds Made Weak: Towards the General Utility of Amides as Synthetic Modules
Author(s) -
Ruider Stefan A.,
Maulide Nuno
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201508536
Subject(s) - amide , peptide bond , bond , combinatorial chemistry , chemistry , carboxylic acid , catalysis , organic chemistry , biochemical engineering , business , engineering , finance , enzyme
Breaking good : The amide bond is widely recognized as the strongest bond among the carboxylic acid derivatives. Therefore, the potential of amides to serve as synthetic building blocks has remained mostly untapped thus far. This Highlight describes a recent breakthrough that enables the catalytic conversion of amides into esters for the first time.