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Cobalt‐Catalyzed Alkylation of Aromatic Amines by Alcohols
Author(s) -
Rösler Sina,
Ertl Michael,
Irrgang Torsten,
Kempe Rhett
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201507955
Subject(s) - alkylation , catalysis , chemistry , cobalt , homogeneous catalysis , organic chemistry , selectivity , homogeneous , ligand (biochemistry) , hydrogen , metal , combinatorial chemistry , noble metal , biochemistry , physics , receptor , thermodynamics
The implementation of inexpensive, Earth‐abundant metals in typical noble‐metal‐mediated chemistry is a major goal in homogeneous catalysis. A sustainable or green reaction that has received a lot of attention in recent years and is preferentially catalyzed by Ir or Ru complexes is the alkylation of amines by alcohols. It is based on the borrowing hydrogen or hydrogen autotransfer concept. Herein, we report on the Co‐catalyzed alkylation of aromatic amines by alcohols. The reaction proceeds under mild conditions, and selectively generates monoalkylated amines. The observed selectivity allows the synthesis of unsymmetrically substituted diamines. A novel Co complex stabilized by a PN 5 P ligand catalyzes the reactions most efficiently.