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Expanding the Ligand Framework Diversity of Carbodicarbenes and Direct Detection of Boron Activation in the Methylation of Amines with CO 2
Author(s) -
Chen WenChing,
Shen JiunShian,
Jurca Titel,
Peng ChunJung,
Lin YenHsu,
Wang YiPing,
Shih WeiChih,
Yap Glenn P. A.,
Ong TiowGan
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201507921
Subject(s) - synthon , amine gas treating , ligand (biochemistry) , chemistry , reactivity (psychology) , methylation , boron , combinatorial chemistry , surface modification , stereochemistry , organic chemistry , biochemistry , receptor , dna , pathology , medicine , alternative medicine
A simple and convergent synthetic strategy used to increase the diversity of the carbodicarbene ligand framework through incorporation of unsymmetrical pendant groups is reported. Structural analysis and spectroscopic studies of ligands and their Rh complexes are reported. Reactivity studies reveal carbodicarbenes as competent organocatalysts for amine methylation using CO 2 as a synthon. A unique BH‐activated boron–carbodicarbene complex was isolated as a reaction intermediate, providing mechanistic insight into the CO 2 functionalization process.