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2D NMR Trace Analysis by Continuous Hyperpolarization at High Magnetic Field
Author(s) -
Eshuis Nan,
Aspers Ruud L. E. G.,
van Weerdenburg Bram J. A.,
Feiters Martin C.,
Rutjes Floris P. J. T.,
Wijmenga Sybren S.,
Tessari Marco
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201507831
Subject(s) - hyperpolarization (physics) , analyte , sensitivity (control systems) , nuclear magnetic resonance , chemistry , signal (programming language) , nuclear magnetic resonance spectroscopy , magnetic field , analytical chemistry (journal) , two dimensional nuclear magnetic resonance spectroscopy , biological system , physics , chromatography , computer science , electronic engineering , engineering , quantum mechanics , programming language , biology
Nuclear magnetic resonance is often the technique of choice in chemical analysis because of its sensitivity to molecular structure, quantitative character, and straightforward sample preparation. However, determination of trace analytes in complex mixtures is generally limited by low sensitivity and extensive signal overlap. Here, we present an approach for continuous hyperpolarization at high magnetic field that is based on signal amplification by reversible exchange (SABRE) and can be straightforwardly incorporated in multidimensional NMR experiments. This method was implemented in a 2D correlation experiment that allows detection and quantification of analytes at nanomolar concentration in complex solutions.