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Ruthenium Oxidase Catalysis for Site‐Selective C–H Alkenylations with Ambient O 2 as the Sole Oxidant
Author(s) -
Bechtoldt Alexander,
Tirler Carina,
Raghuvanshi Keshav,
Warratz Svenja,
Kornhaaß Christoph,
Ackermann Lutz
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201507801
Subject(s) - ruthenium , catalysis , chemistry , selectivity , substrate (aquarium) , combinatorial chemistry , oxidative phosphorylation , turnover number , photochemistry , organic chemistry , biochemistry , oceanography , geology
Ruthenium(II) oxidase catalysis by direct dioxygen‐coupled turnover enabled step‐economical oxidative CH alkenylation reactions at ambient pressure. Versatile ruthenium(II) biscarboxylate catalysts displayed ample substrate scope and proved applicable to weakly coordinating and removable directing groups. The twofold CH functionalization strategy was characterized by exceedingly mild reaction conditions as well as excellent positional selectivity.