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Arrestin‐Bound Rhodopsin: A Molecular Structure and its Impact on the Development of Biased GPCR Ligands
Author(s) -
Möller Dorothee,
Gmeiner Peter
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201507724
Subject(s) - rhodopsin , g protein coupled receptor , computer science , signal transducing adaptor protein , computational biology , chemistry , information retrieval , biology , receptor , biochemistry , retinal
Freeze, you’re under arrest : Serial femtosecond crystallography was used to solve the first high‐resolution structure of the G‐protein‐coupled receptor rhodopsin bound to the adaptor protein arrestin. This template may be useful for the structure‐based design of functionally selective drugs.