Palladium‐Catalyzed Regioselective Diarylation of  o ‐Carboranes By Direct Cage B−H Activation | Zendy

Quan Yangjian | Zendy; Xie Zuowei | Zendy

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Palladium‐Catalyzed Regioselective Diarylation of o ‐Carboranes By Direct Cage B−H Activation

Author(s) -

Quan Yangjian,

Xie Zuowei

Publication year - 2016

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201507697

Subject(s) - regioselectivity , palladium , chemistry , intermolecular force , catalysis , selectivity , cage , medicinal chemistry , coupling (piping) , combinatorial chemistry , organic chemistry , molecule , materials science , mathematics , combinatorics , metallurgy

Palladium‐catalyzed intermolecular coupling of o ‐carborane with aromatics by direct cage B−H bond activation has been achieved, leading to the synthesis of a series of cage B(4,5)‐diarylated‐ o ‐carboranes in high yields with excellent regioselectivity. Traceless directing group ‐COOH plays a crucial role for site‐ and di‐selectivity of such intermolecular coupling reaction. A Pd II –Pd IV –Pd II catalytic cycle is proposed to be responsible for the stepwise arylation.

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