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Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms
Author(s) -
Büschleb Martin,
Dorich Stéphane,
Hanessian Stephen,
Tao Daniel,
Schenthal Kyle B.,
Overman Larry E.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201507549
Subject(s) - stereocenter , quaternary carbon , natural product , quaternary , natural (archaeology) , compendium , carbon fibers , chemistry , stereochemistry , enantioselective synthesis , computer science , organic chemistry , biology , paleontology , catalysis , geography , composite number , archaeology , algorithm
Strategies for the total synthesis of complex natural products that contain two or more contiguous stereogenic quaternary carbon atoms in their intricate structures are reviewed with 12 representative examples. Emphasis has been put on methods to create quaternary carbon stereocenters, including syntheses of the same natural product by different groups, thereby showcasing the diversity of thought and individual creativity. A compendium of selected natural products containing two or more contiguous stereogenic quaternary carbon atoms and key reactions in their total or partial syntheses is provided in the Supporting Information.