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Photocatalytically Renewable Micro‐electrochemical Sensor for Real‐Time Monitoring of Cells
Author(s) -
Xu JiaQuan,
Liu YanLing,
Wang Qian,
Duo HuanHuan,
Zhang XinWei,
Li YuTao,
Huang WeiHua
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201507354
Subject(s) - materials science , graphene , passivation , photocatalysis , electrochemistry , nanotechnology , electrode , oxide , biosensor , nanoparticle , electrochemical gas sensor , chemical engineering , chemistry , catalysis , metallurgy , biochemistry , layer (electronics) , engineering
Electrode fouling and passivation is a substantial and inevitable limitation in electrochemical biosensing, and it is a great challenge to efficiently remove the contaminant without changing the surface structure and electrochemical performance. Herein, we propose a versatile and efficient strategy based on photocatalytic cleaning to construct renewable electrochemical sensors for cell analysis. This kind of sensor was fabricated by controllable assembly of reduced graphene oxide (RGO) and TiO 2 to form a sandwiching RGO@TiO 2 structure, followed by deposition of Au nanoparticles (NPs) onto the RGO shell. The Au NPs‐RGO composite shell provides high electrochemical performance. Meanwhile, the encapsulated TiO 2 ensures an excellent photocatalytic cleaning property. Application of this renewable microsensor for detection of nitric oxide (NO) release from cells demonstrates the great potential of this strategy in electrode regeneration and biosensing.