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CH Photooxygenation of Alkyl Benzenes Catalyzed by Riboflavin Tetraacetate and a Non‐Heme Iron Catalyst
Author(s) -
Mühldorf Bernd,
Wolf Robert
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201507170
Subject(s) - chemistry , alkyl , catalysis , benzene , photooxygenation , medicinal chemistry , photocatalysis , photochemistry , organic chemistry , oxygen , singlet oxygen
A mixture of the photocatalyst riboflavin tetraacetate (RFT) and the biomimetic non‐heme iron complex [Fe(TPA)(MeCN) 2 ](ClO 4 ) 2 (TPA=tris(2‐pyridylmethyl)amine) efficiently catalyzes the visible‐light‐driven aerobic oxidation of alkyl benzenes to ketones and carboxylic acids. An RFT‐catalyzed photocycle and the independent action of the iron complex as a catalyst for H 2 O 2 disproportionation and alkyl benzene oxygenation ensure high yields and selectivities.