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Catalytic Enantioselective Functionalization of Unactivated Terminal Alkenes
Author(s) -
Coombs John R.,
Morken James P.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201507151
Subject(s) - enantioselective synthesis , catalysis , chemistry , terminal (telecommunication) , alkene , organic synthesis , organic chemistry , combinatorial chemistry , chemical synthesis , surface modification , computer science , telecommunications , biochemistry , in vitro
Terminal alkenes are readily available functional groups which appear in α‐olefins produced by the chemical industry, and they appear in the products of many contemporary synthetic reactions. While the organic transformations that apply to alkenes are amongst the most studied reactions in all of chemical synthesis, the number of reactions that apply to nonactivated terminal alkenes in a catalytic enantioselective fashion is small in number. This Minireview highlights the cases where stereocontrol in catalytic reactions of 1‐alkenes is high enough to be useful for asymmetric synthesis.