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Gold Nanoparticles Supported on a Layered Double Hydroxide as Efficient Catalysts for the One‐Pot Synthesis of Flavones
Author(s) -
Yatabe Takafumi,
Jin Xiongjie,
Yamaguchi Kazuya,
Mizuno Noritaka
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201507134
Subject(s) - flavones , catalysis , hydroxide , reagent , chemistry , combinatorial chemistry , nanoparticle , colloidal gold , organic chemistry , stoichiometry , sequence (biology) , nanotechnology , materials science , chromatography , biochemistry
Flavones are a class of natural products with diverse biological activities and have frequently been synthesized by step‐by‐step procedures using stoichiometric amounts of reagents. Herein, a catalytic one‐pot procedure for the synthesis of flavone and its derivatives is developed. In the presence of gold nanoparticles supported on a Mg‐Al layered double hydroxide (Au/LDH), various kinds of flavones can be synthesized starting from 2′‐hydroxyacetophenones and benzaldehydes (or benzyl alcohols). The present one‐pot procedure consists of a sequence of several reactions, and Au/LDH can catalyze all these different types of reactions. The catalysis is shown to be truly heterogeneous, and Au/LDH can be readily recovered and reused.