Natural 1,3‐Dipolar Cycloadditions | Zendy

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Natural 1,3‐Dipolar Cycloadditions

Author(s) -

Baunach Martin,

Hertweck Christian

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201507120

Subject(s) - chemistry , cycloaddition , natural product , nitrone , alkene , biomimetic synthesis , biosynthesis , stereochemistry , ylide , intramolecular force , azomethine ylide , decarboxylation , 1,3 dipolar cycloaddition , enzyme , organic chemistry , catalysis

[3+2] in the wild : Biomimetic natural product syntheses and theoretical considerations have indicated that 1,3‐dipolar cycloadditions take place in nature. Now, the structure, biosynthesis, and function of a heavily modified prenylated flavin cofactor have been elucidated. In the azomethine ylide form, it undergoes [3+2] cycloadditions with aromatic acids and promotes their decarboxylation.

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