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Elusive Reaction Intermediates in Solution Explored by ESI‐MS: Reverse Periscope for Mechanistic Investigations
Author(s) -
Iacobucci Claudio,
Reale Samantha,
De Angelis Francesco
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201507088
Subject(s) - chemical reaction , homogeneous , reaction intermediate , chemistry , mass spectrometry , characterization (materials science) , reactive intermediate , chemical evolution , electrospray , submarine , nanotechnology , materials science , computer science , organic chemistry , chromatography , physics , geology , catalysis , stars , oceanography , thermodynamics , computer vision
Just as periscopes allow a submarine to visually search for objects above the surface of the sea, in a reversed periscope fashion electrospray mass spectrometry (ESI‐MS) can analyze the compounds at the gas phase/liquid phase interface for chemical entities which may exist in solution. The challenge is the identification and structural characterization of key elusive reaction intermediates in chemical transformations, intermediates which are able to explain how chemical processes occur. This Minireview summarizes recent selected publications on the use of ESI‐MS techniques for studying solution intermediates of homogeneous chemical reactions.