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Manganese(I)‐Catalyzed C–H Aminocarbonylation of Heteroarenes
Author(s) -
Liu Weiping,
Bang Jonas,
Zhang Yujiao,
Ackermann Lutz
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201507087
Subject(s) - manganese , catalysis , aryl , alkyl , chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry
A versatile manganese(I) catalyst was employed in CH aminocarbonylation reactions of heteroarenes with aryl as well as with alkyl isocyanates using a removable directing group approach. Detailed experimental mechanistic studies were suggestive of an organometallic CH manganesation step, followed by a rate‐determining migratory insertion.