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An Organocatalytic Biomimetic Strategy Paves the Way for the Asymmetric Umpolung of Imines
Author(s) -
Waser Mario,
Novacek Johanna
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201506872
Subject(s) - umpolung , enantioselective synthesis , organocatalysis , transamination , chemistry , catalysis , combinatorial chemistry , organic chemistry , nucleophile , enzyme
Just like Nature : A recently developed enantioselective organocatalytic biomimetic transamination provides an elegant approach towards chiral amines. In the presence of an asymmetric phase‐transfer catalyst, the intermediate anionic species undergoes an asymmetric CC bond‐forming reaction in a powerful and broadly applicable asymmetric umpolung strategy.