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Formal Direct Cross‐Coupling of Phenols with Amines
Author(s) -
Chen Zhengwang,
Zeng Huiying,
Girard Simon A.,
Wang Feng,
Chen Ning,
Li ChaoJun
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201506751
Subject(s) - amination , phenols , aryl , halide , coupling reaction , chemistry , palladium , catalysis , organic chemistry , coupling (piping) , combinatorial chemistry , materials science , alkyl , metallurgy
The transition‐metal‐catalyzed amination of aryl halides has been the most powerful method for the formation of aryl amines over the past decades. Phenols are regarded as ideal alternatives to aryl halides as coupling partners in cross‐couplings. An efficient palladium‐catalyzed formal cross‐coupling of phenols with various amines and anilines has now been developed. A variety of substituted phenols were compatible with the standard reaction conditions. Secondary and tertiary aryl amines could thus be synthesized in moderate to excellent yields.