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Palladium‐Catalyzed Catellani ortho ‐Acylation Reaction: An Efficient and Regiospecific Synthesis of Diaryl Ketones
Author(s) -
Huang Yunze,
Zhu Rui,
Zhao Kun,
Gu Zhenhua
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201506446
Subject(s) - acylation , reagent , chemistry , palladium , catalysis , acid anhydride , organic chemistry , stoichiometry , epoxy
A palladium‐catalyzed, norbornene‐mediated Catellani ortho ‐acylation reaction was developed by the use of either acyl chlorides or acid anhydrides as acylation reagents. The addition of more than a stoichiometric amount of H 2 O is crucial for this transformation when acid chlorides are used, and kinetic studies indicate that the active acylation reagent is possibly an acid anhydride.