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Rhodium(III)‐Catalyzed Amidation of Unactivated C(sp 3 )H Bonds
Author(s) -
Wang He,
Tang Guodong,
Li Xingwei
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201506323
Subject(s) - rhodium , catalysis , chemistry , surface modification , amide , hydrogen bond , combinatorial chemistry , medicinal chemistry , stereochemistry , molecule , organic chemistry
Nitrogenation by direct functionalization of CH bonds represents an important strategy for constructing CN bonds. Rhodium(III)‐catalyzed direct amidation of unactivated C(sp 3 )H bonds is rare, especially under mild reaction conditions. Herein, a broad scope of C(sp 3 )H bonds are amidated under rhodium catalysis in high efficiency using 3‐substituted 1,4,2‐dioxazol‐5‐ones as the amide source. The protocol broadens the scope of rhodium(III)‐catalyzed C(sp 3 )H activation chemistry, and is applicable to the late‐stage functionalization of natural products.