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Aerobic Asymmetric Dehydrogenative Cross‐Coupling between Two C sp 3 H Groups Catalyzed by a Chiral‐at‐Metal Rhodium Complex
Author(s) -
Tan Yuqi,
Yuan Wei,
Gong Lei,
Meggers Eric
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201506273
Subject(s) - rhodium , stereocenter , enantioselective synthesis , autoxidation , catalysis , chemistry , photochemistry , organocatalysis , combinatorial chemistry , organic chemistry
A sustainable CC bond formation is merged with the catalytic asymmetric generation of one or two stereocenters. The introduced catalytic asymmetric cross‐coupling of two C sp 3H groups with molecular oxygen as the oxidant profits from the oxidative robustness of a chiral‐at‐metal rhodium(III) catalyst and exploits an autoxidation mechanism or visible‐light photosensitized oxidation. In the latter case, the catalyst serves a dual function, namely as a chiral Lewis acid for catalyzing enantioselective enolate chemistry and at the same time as a visible‐light‐driven photoredox catalyst.