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Inside Cover: Pyridylidene‐Mediated Dihydrogen Activation Coupled with Catalytic Imine Reduction (Angew. Chem. Int. Ed. 33/2015)
Author(s) -
Auth Johanna,
Padevet Jaroslav,
Mauleón Pablo,
Pfaltz Andreas
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201506235
Subject(s) - pyridinium , imine , chemistry , catalysis , trifluoromethanesulfonate , medicinal chemistry , ketone , amine gas treating , hydride , protonation , polymer chemistry , hydrogen , organic chemistry , ion
The trapping of H 2 with a pyridylidene generated from a pyridinium salt and base is reported by A. Pfaltz, P. Mauleón et al. in their Communication on page 9542 ff. By coupling H 2 activation with subsequent hydride transfer to an imine, a catalytic process was established. Treatment of the N ‐phenylimine of phenyl trifluoromethyl ketone with N‐ mesityl‐3,5‐bis(2,6‐dimethylphenyl)pyridinium triflate and LiN(SiMe 3 ) 2 under 50 bar of H 2 resulted in high conversion into the corresponding amine.