Identification of Intermediates in the Biosynthesis of PR Toxin by  Penicillium roqueforti | Zendy

Riclea Ramona | Zendy; Dickschat Jeroen S. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Identification of Intermediates in the Biosynthesis of PR Toxin by Penicillium roqueforti

Author(s) -

Riclea Ramona,

Dickschat Jeroen S.

Publication year - 2015

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201506128

Subject(s) - penicillium roqueforti , toxin , biosynthesis , identification (biology) , penicillium , microbiology and biotechnology , chemistry , biology , computational biology , biochemistry , genetics , enzyme , ecology

The sesquiterpenoid 7‐ epi ‐neopetasone was synthesized via the Wieland–Miescher ketone. The compound was identical to a previously tentatively identified headspace constituent of Penicillium roqueforti. Feeding experiments with 13 C‐labeled mevalonolactone isotopomers demonstrated that oxidation at C12 and an isomerization of the C11C12 to a C7C11 double bond must occur independently and not via a C7‐C11‐C12 allyl radical in one step. Feeding with (11,12,13‐ 13 C 3 )‐7‐ epi ‐neopetasone resulted in labelling of the PR toxin, thus establishing this compound as a newly identified pathway intermediate.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research