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Highly Regioselective Radical Amination of Allenes: Direct Synthesis of Allenamides and Tetrasubstituted Alkenes
Author(s) -
Zhang Ge,
Xiong Tao,
Wang Zining,
Xu Guoxing,
Wang Xuedan,
Zhang Qian
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201506066
Subject(s) - regioselectivity , amination , allene , chemistry , organic chemistry , combinatorial chemistry , catalysis
The first controllable, regioselective radical amination of allenes with N ‐fluoroarylsulfonimide is described to proceed under very mild reaction conditions. With this methodology, a general and straightforward route for the synthesis of both allenamides and fluorinated tetrasubstituted alkenes was realized from a wide range of terminal and internal allenes.