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Asymmetric Brønsted Acid Catalyzed Synthesis of Triarylmethanes—Construction of Communesin and Spiroindoline Scaffolds
Author(s) -
Liao HsuanHung,
Chatupheeraphat Adisak,
Hsiao ChienChi,
Atodiresei Iuliana,
Rueping Magnus
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201505981
Subject(s) - catalysis , brønsted–lowry acid–base theory , chemistry , combinatorial chemistry , organic chemistry
Aza‐ ortho ‐quinone methides allow the straightforward asymmetric synthesis of natural‐product‐inspired indole scaffolds possessing a quaternary stereocenter. Our approach provides access to diverse communesin and spiroindoline derivatives with high enantioselectivity under mild reaction conditions. Predictable substitution patterns are found to be the key to our regiodivergent protocols.