Premium
Inside Back Cover: Short and Divergent Total Synthesis of (+)‐Machaeriol B, (+)‐Machaeriol D, (+)‐Δ 8 ‐THC, and Analogues (Angew. Chem. Int. Ed. 29/2015)
Author(s) -
Klotter Felix,
Studer Armido
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201505496
Subject(s) - stereoselectivity , stereospecificity , hydroboration , cover (algebra) , chemistry , stereochemistry , total synthesis , palladium , int , sequence (biology) , combinatorial chemistry , catalysis , organic chemistry , mechanical engineering , biochemistry , computer science , engineering , operating system
Machaeriols and cannabinoids can be synthesized by a short and divergent approach featuring highly efficient stereoselective transformations from a common precursor, commercially available ( S )‐perillic acid. In their Communication on page 8547 ff., A. Studer and F. Klotter report the use of a stereospecific palladium‐catalyzed decarboxylative γ‐arylation and a one‐pot sequence comprising a stereoselective hydroboration followed by oxidation or reduction as key steps.