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Isoniazid@Fe 2 O 3 Nanocontainers and Their Antibacterial Effect on Tuberculosis Mycobacteria
Author(s) -
Leidinger Peter,
Treptow Jens,
Hagens Kristine,
Eich Jacqueline,
Zehethofer Nicole,
Schwudke Dominik,
Oehlmann Wulf,
Lünsdorf Heinrich,
Goldmann Oliver,
Schaible Ulrich E.,
Dittmar Kurt E. J.,
Feldmann Claus
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201505493
Subject(s) - isoniazid , mycobacterium tuberculosis , tuberculosis , mycobacterium , microbiology and biotechnology , chemistry , materials science , nuclear chemistry , medicine , biology , pathology
Isoniazid‐filled Fe 2 O 3 hollow nanospheres (INH@Fe 2 O 3 , diameter <30 nm, 48 wt % INH‐load) are prepared for the first time and suggested for tuberculosis therapy. After dextran‐functionalization, the INH@Fe 2 O 3 @DEX nanocontainers show strong activity against Mycobacterium tuberculosis (M.tb.) and M.tb.‐infected macrophages. The nanocontainers can be considered as “Trojan horses” and show efficient, active uptake into both M.tb.‐infected macrophages and even into mycobacterial cells.