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A Stimuli‐Responsive Rotaxane–Gold Catalyst: Regulation of Activity and Diastereoselectivity
Author(s) -
Galli Marzia,
Lewis James E. M.,
Goldup Stephen M.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201505464
Subject(s) - rotaxane , catalysis , selectivity , chemistry , ligand (biochemistry) , cofactor , yield (engineering) , photochemistry , combinatorial chemistry , stereochemistry , materials science , organic chemistry , receptor , molecule , biochemistry , supramolecular chemistry , enzyme , metallurgy
A rotaxane‐based Au catalyst was developed and the effect of the mechanical bond on its behavior was studied. Unlike the non‐interlocked thread, the rotaxane requires a catalytically innocent cofactor, the identity of which significantly influences both the yield and diastereoselectivity of the reaction. Under optimized conditions, Au I (the catalyst), Ag I (to abstract the Cl − ligand), and Cu I (the cofactor) combine to produce a catalyst with excellent activity and selectivity.