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The Microbes inside Us and the Race for Colibactin
Author(s) -
Bode Helge B.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201505341
Subject(s) - race (biology) , bacteria , human health , biology , gut bacteria , biosynthesis , human disease , arms race , human microbiome , microbiology and biotechnology , genetics , gene , microbiome , medicine , environmental health , sociology , botany , political economy
Gut reaction : There is increasing evidence that the impact on human health and disease of the microbes living in and on us has been underestimated. Several of the small molecules produced by “our” bacteria are structurally highly complex and show unusual biosynthetic pathways or modes of action, as highlighted by the race to elucidate the structure and biosynthesis of colibactin, a genotoxic compound produced by human gut bacteria.