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Structure Elucidation and Characterization of Different Thyroxine Polymorphs
Author(s) -
Mondal Santanu,
Mugesh Govindasamy
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201505281
Subject(s) - chemistry , hormone , reactivity (psychology) , polymorphism (computer science) , solubility , halogen bond , thyroid hormones , medicine , biochemistry , halogen , organic chemistry , allele , alternative medicine , alkyl , pathology , gene
Thyroid hormones regulate almost every process in the body, including body temperature, growth, and heart rate. They influence carbohydrate metabolism, protein synthesis and breakdown, and cardiovascular, renal, and brain function. Two new polymorphs of synthetic L ‐thyroxine (T4) are reported and the effect of polymorphism on the solubility of this important hormone is shown. Conformational changes were also discovered to have a remarkable effect on the strength of halogen bonding and the reactivity of the CI bonds, which could have a significant effect on the hormone activity.