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Uncovering the Role of Metal Catalysis in Tetrazole Formation by an In Situ Cycloaddition Reaction: An Experimental Approach
Author(s) -
Zhong DiChang,
Wen YaQiong,
Deng JiHua,
Luo XuZhong,
Gong YunNan,
Lu TongBu
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201505118
Subject(s) - cycloaddition , tetrazole , in situ , catalysis , metal , chemistry , combinatorial chemistry , organic chemistry
Using an experimental approach, the role of metal catalysis has been investigated in the in situ cycloaddition reaction of nitrile with azide to form tetrazoles. It has been shown that metal catalysis serves to activate the cyano group in the nitrile reagent by a coordinative interaction.