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Inside Cover: Recombinant Expression and Phenotypic Screening of a Bioactive Cyclotide Against α‐Synuclein‐Induced Cytotoxicity in Baker′s Yeast (Angew. Chem. Int. Ed. 29/2015)
Author(s) -
Jagadish Krishnappa,
Gould Andrew,
Borra Radhika,
Majumder Subhabrata,
Mushtaq Zahid,
Shekhtman Alexander,
Camarero Julio A.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201505052
Subject(s) - yeast , heterologous , heterologous expression , recombinant dna , chemistry , cytotoxicity , phenotype , biology , biochemistry , microbiology and biotechnology , computational biology , in vitro , gene
Cyclotides are naturally occurring microproteins with a circular Cys‐knot topology found in plants. In their Communication on page 8390 ff., J. A. Camarero et al. show the heterologous expression of cyclotides inside live yeast cells. This approach was used to produce a cyclotide to inhibit α‐syn‐induced cytotoxity in a synucleopathy model.