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In Vivo Remote Control of Reactions in Caenorhabditis elegans by Using Supramolecular Nanohybrids of Carbon Nanotubes and Liposomes
Author(s) -
Miyako Eijiro,
Chechetka Svetlana A.,
Doi Motomichi,
Yuba Eiji,
Kono Kenji
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201504987
Subject(s) - nanotechnology , liposome , supramolecular chemistry , caenorhabditis elegans , carbon nanotube , molecule , materials science , biophysics , nanomedicine , in vivo , chemistry , nanoparticle , biology , biochemistry , organic chemistry , microbiology and biotechnology , gene
A supramolecular nanohybrid based on carbon nanotubes and liposomes that is highly biocompatible and capable of permeation through cells is described. The nanohybrid can be loaded with a variety of functional molecules and is structurally controlled by near‐infrared laser irradiation for the release of molecules from the nanohybrids in a targeted manner via microscopy. We implemented the controlled release of molecules from the nanohybrids and demonstrated remote regulation of the photoinduced nanohybrid functions. As a proof of principle, nanohybrids loaded with amiloride were successfully used in the spatiotemporally targeted blocking of amiloride‐sensitive mechanosensory neurons in living Caenorhabditis elegans . Our prototype could inspire new designs for biomimetic parasitism and symbiosis, and biologically active nanorobots for the higher‐level manipulation of organisms.