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Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids
Author(s) -
Schimming Olivia,
Challinor Victoria L.,
Tobias Nicholas J.,
Adihou Hélène,
Grün Peter,
Pöschel Laura,
Richter Christian,
Schwalbe Harald,
Bode Helge B.
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201504877
Subject(s) - pyrrolizidine , biosynthesis , bacteria , biochemistry , biology , chemistry , stereochemistry , microbiology and biotechnology , gene , genetics
Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non‐ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram‐negative and Gram‐positive bacteria indicates an important biological function in bacteria.